Increased 5-HT contractile response in late pregnant rat myometrium is associated with a higher density of 5-HT2Areceptors
نویسندگان
چکیده
منابع مشابه
Contractile efficacy of different prostaglandins in pregnant rat myometrium pre- treated with oxytocin
:64 Contractile efficacy of different prostaglandins in pregnant rat myometrium pretreated with oxytocin Presenting Author: Mrinalini Balki MDPresenting Author's Institution: Mount Sinai Hospital, University of Toronto Toronto, OntarioCo-Authors: Nikki Kanwal BSc Mount Sinai Hospital, University of Toronto Toronto, OntarioMagda Erik-Soussi MSc Mount Sinai Hospital, University of Tor...
متن کاملHeterogeneity in 5-HT-induced contractile and proliferative responses in rat pulmonary arterial bed.
AIMS 5-Hydroxytryptamine (5-HT) is a potent vasoconstrictor and mitogen in the pulmonary vascular bed which exhibits phenotypical and functional heterogeneity according to size of the vessels. METHODS We thus investigated both contractile response and smooth muscle cell (SMC) proliferation in response to 5-HT in rat main extrapulmonary artery (MPA) and intrapulmonary arteries of the first and...
متن کاملIncreased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat.
Normal rat pregnancy is characterized by plasma volume expansion due to renal sodium retention and is associated with a blunted response to natriuretic stimuli, such as atrial natriuretic peptide (ANP). ANP signals via cGMP, and phosphodiesterases (PDE) inactivate cGMP and terminate the natriuretic response. We previously reported that increased medullary PDE-5 activity occurs in rat pregnancy,...
متن کاملSignalling pathways involved in the contractile response to 5-HT in the human pulmonary artery.
Serotonin (5-hydroxytryptamine; 5-HT) is a potent pulmonary vasoconstrictor and mitogenic agent whose plasma level is increased in pulmonary hypertensive patients. Thus, we explored the signalling pathways involved in the contractile response to 5-HT in human pulmonary arteries (HPAs). Intact and beta-escin permeabilised rings from HPAs mounted in an organ bath system were used to assess both t...
متن کاملAugmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat.
The present study re-evaluated an existing notion that serotonin (5-hydroxytryptamine; 5-HT) could not cross the brain to the circulating blood via the blood-brain barrier (BBB). To elevate brain 5-HT alone, 5-hydroxytryptophan (5-HTP; 30-75 mg/kg) was administrated intravenously to anaesthetized rats that had undergone gastrointestinal and kidney resections along with liver inactivation (organ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2007
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2007.129726